PDGFC

Gene Information

Official Symbol: PDGFC
Official Name: platelet derived growth factor C
Aliases and Previous Symbols: N/A
Entrez ID: 56034
UniProt: Q9NRA1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. {ECO:0000269|PubMed:10806482, ECO:0000269|PubMed:10858496, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11854040, ECO:0000269|PubMed:12032822, ECO:0000269|PubMed:15061151, ECO:0000269|PubMed:15372073, ECO:0000269|PubMed:15389578, ECO:0000269|PubMed:15728360, ECO:0000269|PubMed:15911618, ECO:0000269|PubMed:16439802, ECO:0000269|PubMed:18055825}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17737
Expression level (log2 read counts): -2.64

Expression Distribution

CUB
PDGF

activation of transmembrane receptor protein tyrosine kinase activity
platelet-derived growth factor receptor binding
positive regulation of protein autophosphorylation
platelet-derived growth factor receptor signaling pathway
regulation of protein autophosphorylation
positive regulation of fibroblast proliferation
cellular response to amino acid stimulus
regulation of fibroblast proliferation
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of cell division
positive regulation of cold-induced thermogenesis
response to amino acid
regulation of phosphatidylinositol 3-kinase signaling
digestive tract development
digestive system development
regulation of cold-induced thermogenesis
growth factor activity
regulation of cell division
bone development
cellular response to acid chemical
positive regulation of ERK1 and ERK2 cascade
regulation of peptidyl-tyrosine phosphorylation
positive regulation of MAP kinase activity
regulation of ERK1 and ERK2 cascade
endoplasmic reticulum lumen
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
response to acid chemical
embryonic organ development
skeletal system development
positive regulation of cell migration
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of protein serine/threonine kinase activity
positive regulation of cell motility
positive regulation of protein kinase activity
positive regulation of cellular component movement
positive regulation of MAPK cascade
positive regulation of locomotion
positive regulation of kinase activity