PDIA2

Entrez Summary: N/A
UniProt Summary: Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins. {ECO:0000269|PubMed:19150607, ECO:0000269|PubMed:19429457}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

disulfide oxidoreductase activity
peptide disulfide oxidoreductase activity
protein retention in ER lumen
maintenance of protein localization in endoplasmic reticulum
protein folding in endoplasmic reticulum
protein disulfide isomerase activity
steroid binding
maintenance of protein localization in organelle
maintenance of protein location in cell
cell redox homeostasis
maintenance of location in cell
maintenance of protein location
protein localization to endoplasmic reticulum
maintenance of location
protein folding
response to endoplasmic reticulum stress
endoplasmic reticulum lumen
protein localization to organelle
cellular homeostasis
oxidation-reduction process
endoplasmic reticulum
cellular protein localization
cellular macromolecule localization
homeostatic process
cellular response to stress