PDLIM5

Entrez Summary: N/A
UniProt Summary: May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

LIM
PDZ

cell growth involved in cardiac muscle cell development
physiological muscle hypertrophy
physiological cardiac muscle hypertrophy
actinin binding
cadherin binding involved in cell-cell adhesion
muscle alpha-actinin binding
cardiac muscle tissue growth
heart growth
cardiac muscle hypertrophy
striated muscle hypertrophy
muscle hypertrophy
filamentous actin
regulation of dendritic spine morphogenesis
protein kinase C binding
cardiac muscle cell development
cardiac cell development
stress fiber
regulation of dendritic spine development
developmental cell growth
cardiac muscle cell differentiation
cell growth
regulation of dendrite morphogenesis
regulation of postsynapse organization
organ growth
regulation of synapse assembly
cell-cell adherens junction
protein N-terminus binding
cardiocyte differentiation
Z disc
striated muscle cell development
muscle cell development
regulation of dendrite development
cardiac muscle tissue development
postsynaptic membrane
striated muscle cell differentiation
actin cytoskeleton
regulation of synapse organization
regulation of synapse structure or activity
muscle cell differentiation
postsynaptic density