PDPR

Entrez Summary: Pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate and links glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. The dephosphorylation and reactivation of PDC is catalyzed by pyruvate dehydrogenase phosphatase (PDP). The dimeric PDP has a catalytic subunit and a regulatory subunit. This gene encodes the FAD-containing regulatory subunit of PDP. The encoded protein acts to decrease the sensitivity of the PDP catalytic subunit to magnesium ions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017].
UniProt Summary: Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of acetyl-CoA biosynthetic process from pyruvate
regulation of acyl-CoA biosynthetic process
regulation of coenzyme metabolic process
regulation of sulfur metabolic process
regulation of cofactor metabolic process
regulation of purine nucleotide biosynthetic process
regulation of nucleotide biosynthetic process
regulation of fatty acid metabolic process
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
oxidoreductase activity
regulation of cellular ketone metabolic process
mitochondrial matrix
regulation of lipid metabolic process
regulation of cellular amide metabolic process
regulation of small molecule metabolic process
oxidation-reduction process
mitochondrion
regulation of phosphate metabolic process
regulation of phosphorus metabolic process