PDXP

Entrez Summary: N/A
UniProt Summary: Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine (PubMed:15580268). Pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'- phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP (PubMed:14522954). {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

vitamin B6 catabolic process
pyridoxal phosphate catabolic process
actin rod assembly
pyridoxal phosphatase activity
water-soluble vitamin catabolic process
phosphoserine phosphatase activity
pyridoxal phosphate metabolic process
vitamin B6 metabolic process
contractile ring
pyridine-containing compound catabolic process
aldehyde catabolic process
vitamin catabolic process
positive regulation of actin filament depolymerization
coenzyme catabolic process
cellular response to ATP
positive regulation of protein depolymerization
lamellipodium membrane
response to ATP
positive regulation of protein complex disassembly
phosphoprotein phosphatase activity
pyridine-containing compound metabolic process
phosphatase activity
regulation of actin filament depolymerization
cellular aldehyde metabolic process
cleavage furrow
heat shock protein binding
cofactor catabolic process
actin filament bundle assembly
actin filament bundle organization
cellular response to nutrient
organic hydroxy compound catabolic process
regulation of protein depolymerization
water-soluble vitamin metabolic process
regulation of cytokinesis
ruffle membrane
regulation of protein complex disassembly
vitamin metabolic process
organophosphate catabolic process
response to organophosphorus
drug catabolic process