PEAK1

Entrez Summary: This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014].
UniProt Summary: Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN. {ECO:0000269|PubMed:20534451}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

focal adhesion assembly
cell-substrate adherens junction assembly
adherens junction assembly
cell-substrate junction assembly
non-membrane spanning protein tyrosine kinase activity
substrate adhesion-dependent cell spreading
regulation of focal adhesion assembly
regulation of cell-substrate junction assembly
regulation of adherens junction organization
adherens junction organization
regulation of cell junction assembly
regulation of cell-matrix adhesion
cell-matrix adhesion
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
cell junction assembly
cell-substrate adhesion
protein autophosphorylation
regulation of cell-substrate adhesion
cell junction organization
actin cytoskeleton
protein kinase activity
focal adhesion
cell morphogenesis involved in differentiation
regulation of cell adhesion
cell morphogenesis
cellular component morphogenesis
peptidyl-amino acid modification
cell adhesion
biological adhesion
regulation of cellular component biogenesis
cell migration
protein phosphorylation
identical protein binding
cell motility
localization of cell
phosphorylation
locomotion
ATP binding
movement of cell or subcellular component