PEMT [The Human Chemical-Genetic Interaction Map Project]

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======= PEMT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PEMT
  * **<color #00a2e8>Official Name</color>**: phosphatidylethanolamine N-methyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10400|10400]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBM1|Q9UBM1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PEMT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PEMT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602391|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PEMT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylethanolamine N-methyltransferase activity|
|phosphatidyl-N-methylethanolamine N-methyltransferase activity|
|phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|
|S-adenosylhomocysteine metabolic process|
|positive regulation of lipoprotein metabolic process|
|sphingomyelin biosynthetic process|
|phosphatidylethanolamine binding|
|regulation of lipoprotein metabolic process|
|sphingomyelin metabolic process|
|S-adenosylmethionine metabolic process|
|blastocyst hatching|
|organism emergence from protective structure|
|hatching|
|phosphatidylcholine biosynthetic process|
|brush border membrane|
|purine ribonucleoside metabolic process|
|purine nucleoside metabolic process|
|ribonucleoside metabolic process|
|phosphatidylcholine metabolic process|
|response to vitamin|
|sphingolipid biosynthetic process|
|positive regulation of cold-induced thermogenesis|
|blastocyst development|
|sarcolemma|
|mitochondrial membrane|
|nucleoside metabolic process|
|response to amino acid|
|response to ethanol|
|membrane lipid biosynthetic process|
|glycosyl compound metabolic process|
|regulation of cold-induced thermogenesis|
|sphingolipid metabolic process|
|ammonium ion metabolic process|
|cellular modified amino acid metabolic process|
|membrane lipid metabolic process|
|glycerophospholipid biosynthetic process|
|alpha-amino acid metabolic process|
|response to nutrient|
|glycerolipid biosynthetic process|
|response to alcohol|
|phospholipid biosynthetic process|
|coenzyme metabolic process|
|response to antibiotic|
|glycerophospholipid metabolic process|
|cellular amino acid metabolic process|
|methylation|
|response to acid chemical|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|phospholipid metabolic process|
|in utero embryonic development|
|glycerolipid metabolic process|
|cofactor metabolic process|
|response to nutrient levels|
|drug metabolic process|
|response to toxic substance|
|amide biosynthetic process|
|response to extracellular stimulus|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|negative regulation of cell population proliferation|
|cellular amide metabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|embryo development|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|response to nitrogen compound|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.19|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16274
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PEMT Expression in NALM6 Cells: 3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>