PEMT
Gene Information
- Official Symbol: PEMT
- Official Name: phosphatidylethanolamine N-methyltransferase
- Aliases and Previous Symbols: N/A
- Entrez ID: 10400
- UniProt: Q9UBM1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PEMT |
GO Terms
| phosphatidylethanolamine N-methyltransferase activity |
| phosphatidyl-N-methylethanolamine N-methyltransferase activity |
| phosphatidyl-N-dimethylethanolamine N-methyltransferase activity |
| S-adenosylhomocysteine metabolic process |
| positive regulation of lipoprotein metabolic process |
| sphingomyelin biosynthetic process |
| phosphatidylethanolamine binding |
| regulation of lipoprotein metabolic process |
| sphingomyelin metabolic process |
| S-adenosylmethionine metabolic process |
| blastocyst hatching |
| organism emergence from protective structure |
| hatching |
| phosphatidylcholine biosynthetic process |
| brush border membrane |
| purine ribonucleoside metabolic process |
| purine nucleoside metabolic process |
| ribonucleoside metabolic process |
| phosphatidylcholine metabolic process |
| response to vitamin |
| sphingolipid biosynthetic process |
| positive regulation of cold-induced thermogenesis |
| blastocyst development |
| sarcolemma |
| mitochondrial membrane |
| nucleoside metabolic process |
| response to amino acid |
| response to ethanol |
| membrane lipid biosynthetic process |
| glycosyl compound metabolic process |
| regulation of cold-induced thermogenesis |
| sphingolipid metabolic process |
| ammonium ion metabolic process |
| cellular modified amino acid metabolic process |
| membrane lipid metabolic process |
| glycerophospholipid biosynthetic process |
| alpha-amino acid metabolic process |
| response to nutrient |
| glycerolipid biosynthetic process |
| response to alcohol |
| phospholipid biosynthetic process |
| coenzyme metabolic process |
| response to antibiotic |
| glycerophospholipid metabolic process |
| cellular amino acid metabolic process |
| methylation |
| response to acid chemical |
| sulfur compound metabolic process |
| purine-containing compound metabolic process |
| phospholipid metabolic process |
| in utero embryonic development |
| glycerolipid metabolic process |
| cofactor metabolic process |
| response to nutrient levels |
| drug metabolic process |
| response to toxic substance |
| amide biosynthetic process |
| response to extracellular stimulus |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| lipid biosynthetic process |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| negative regulation of cell population proliferation |
| cellular amide metabolic process |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| embryo development |
| response to organonitrogen compound |
| oxoacid metabolic process |
| response to drug |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| response to nitrogen compound |
| lipid metabolic process |
| organonitrogen compound biosynthetic process |
| response to oxygen-containing compound |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CCT251545 0.2μM R06 exp271 | -2.19 |
| Temozolomide 200μM R04 exp189 | 2.1 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16274
- Expression level (log2 read counts): 3.28
Expression Distribution
PEMT Expression in NALM6 Cells: 3.28
