PGAM4

Entrez Summary: This intronless gene appears to have arisen from a retrotransposition event, yet it is thought to be an expressed, protein-coding gene. The encoded protein is a member of the phosphoglycerate mutase family, a set of enzymes that catalyze the transfer of a phosphate group from 3-phosphoglycerate to 2-phosphoglycerate. [provided by RefSeq, May 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
Alpha-Amanitin 0.5μM R00 exp5	-1.7
Ammonium tetrathiomolybdate 10μM R08 exp448	1.86

phosphoglycerate mutase activity
bisphosphoglycerate mutase activity
positive regulation of flagellated sperm motility
positive regulation of cilium-dependent cell motility
regulation of flagellated sperm motility
sperm principal piece
regulation of cilium-dependent cell motility
glycolytic process
ATP generation from ADP
ADP metabolic process
nucleoside diphosphate phosphorylation
purine nucleoside diphosphate metabolic process
nucleotide phosphorylation
purine ribonucleoside diphosphate metabolic process
ribonucleoside diphosphate metabolic process
pyruvate metabolic process
hydrolase activity
positive regulation of reproductive process
nucleoside diphosphate metabolic process
carbohydrate catabolic process
regulation of reproductive process
ATP metabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
generation of precursor metabolites and energy
nucleotide metabolic process
nucleoside phosphate metabolic process
carbohydrate metabolic process
positive regulation of cell motility
monocarboxylic acid metabolic process
positive regulation of cellular component movement
nucleobase-containing small molecule metabolic process
positive regulation of locomotion
organophosphate metabolic process
carboxylic acid metabolic process
regulation of cell motility
regulation of locomotion