PHACTR1 [The Human Chemical-Genetic Interaction Map Project]

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======= PHACTR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHACTR1
  * **<color #00a2e8>Official Name</color>**: phosphatase and actin regulator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=221692|221692]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9C0D0|Q9C0D0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHACTR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHACTR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608723|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in cell motility. Plays a role in the formation of tubules by endothelial cells. Regulates PPP1CA activity. Required for normal cell survival. {ECO:0000269|PubMed:21798305, ECO:0000269|PubMed:21939755}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RPEL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dendrite arborization|
|neuron projection arborization|
|contractile actin filament bundle assembly|
|stress fiber assembly|
|protein phosphatase 1 binding|
|protein phosphatase inhibitor activity|
|regulation of neuron migration|
|dendrite morphogenesis|
|negative regulation of phosphoprotein phosphatase activity|
|actin filament bundle assembly|
|actin cytoskeleton reorganization|
|negative regulation of protein dephosphorylation|
|actin filament bundle organization|
|dendrite development|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|actomyosin structure organization|
|cerebral cortex development|
|regulation of phosphoprotein phosphatase activity|
|regulation of protein dephosphorylation|
|pallium development|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|actin filament organization|
|telencephalon development|
|actin binding|
|synapse|
|forebrain development|
|cell morphogenesis involved in neuron differentiation|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|cell part morphogenesis|
|cell junction|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|actin filament-based process|
|negative regulation of protein modification process|
|neuron projection development|
|cell morphogenesis|
|brain development|
|head development|
|negative regulation of catalytic activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|localization of cell|
|cell motility|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|regulation of hydrolase activity|
|locomotion|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11305
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHACTR1 Expression in NALM6 Cells: 7.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>