PHF14 [The Human Chemical-Genetic Interaction Map Project]

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======= PHF14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHF14
  * **<color #00a2e8>Official Name</color>**: PHD finger protein 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9678|9678]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94880|O94880]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHF14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHF14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619907|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of mesenchymal cell proliferation involved in lung development|
|negative regulation of platelet-derived growth factor receptor-alpha signaling pathway|
|negative regulation of mesenchymal cell proliferation involved in lung development|
|regulation of platelet-derived growth factor receptor-alpha signaling pathway|
|negative regulation of mesenchymal cell proliferation|
|negative regulation of platelet-derived growth factor receptor signaling pathway|
|regulation of platelet-derived growth factor receptor signaling pathway|
|regulation of mesenchymal cell proliferation|
|lung alveolus development|
|lung development|
|respiratory tube development|
|respiratory system development|
|negative regulation of cell population proliferation|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of developmental process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.95|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.71|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.76|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.83|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.36|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.39|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.7|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17807
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHF14 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>