PHF17
Gene Information
- Official Symbol: JADE1
- Official Name: jade family PHD finger 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 79960
- UniProt: Q6IE81
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| EPL1 |
| PHD |
GO Terms
| histone H4-K12 acetylation |
| histone H4-K8 acetylation |
| histone H4-K5 acetylation |
| histone H4-K16 acetylation |
| histone acetyltransferase complex |
| histone H3 acetylation |
| histone H4 acetylation |
| negative regulation of G1/S transition of mitotic cell cycle |
| negative regulation of cell cycle G1/S phase transition |
| histone acetylation |
| internal peptidyl-lysine acetylation |
| peptidyl-lysine acetylation |
| internal protein amino acid acetylation |
| ciliary basal body |
| protein acetylation |
| regulation of G1/S transition of mitotic cell cycle |
| regulation of cell cycle G1/S phase transition |
| negative regulation of canonical Wnt signaling pathway |
| negative regulation of cell growth |
| protein acylation |
| negative regulation of Wnt signaling pathway |
| negative regulation of mitotic cell cycle phase transition |
| negative regulation of cell cycle phase transition |
| negative regulation of growth |
| regulation of canonical Wnt signaling pathway |
| transcription coactivator activity |
| negative regulation of mitotic cell cycle |
| peptidyl-lysine modification |
| negative regulation of cell cycle process |
| regulation of Wnt signaling pathway |
| histone modification |
| covalent chromatin modification |
| nuclear speck |
| regulation of mitotic cell cycle phase transition |
| regulation of cell growth |
| regulation of cell cycle phase transition |
| negative regulation of cell cycle |
| regulation of mitotic cell cycle |
| regulation of growth |
| chromatin organization |
| regulation of cell cycle process |
| peptidyl-amino acid modification |
| apoptotic process |
| programmed cell death |
| chromosome organization |
| cell death |
| regulation of cell cycle |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Methotrexate 0.01μM R08 exp501 | -2.13 |
| Rapamycin 10μM R00 exp30 | -1.79 |
| HMS-I1 10μM R06 exp256 | -1.72 |
| ABT-702 5μM R06 exp261 | -1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4194
- Expression level (log2 read counts): 7.01
Expression Distribution
PHF17 Expression in NALM6 Cells: 7.01
