PHOX2B

Entrez Summary: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016].
UniProt Summary: Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum- response element.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

efferent axon development in a lateral line nerve
retrotrapezoid nucleus neuron differentiation
retrotrapezoid nucleus development
medullary reticular formation development
lateral line nerve development
lateral line system development
medulla oblongata development
noradrenergic neuron development
hindbrain tangential cell migration
neural crest cell migration involved in autonomic nervous system development
brainstem development
noradrenergic neuron differentiation
sympathetic ganglion development
enteric nervous system development
regulation of respiratory gaseous exchange by nervous system process
cell migration in hindbrain
regulation of respiratory system process
ganglion development
cell differentiation in hindbrain
parasympathetic nervous system development
sympathetic nervous system development
regulation of respiratory gaseous exchange
negative regulation of cell cycle arrest
positive regulation of G2/M transition of mitotic cell cycle
positive regulation of cell cycle G2/M phase transition
dopaminergic neuron differentiation
central nervous system neuron axonogenesis
autonomic nervous system development
skeletal muscle cell differentiation
cranial nerve development
neural crest cell migration
neural nucleus development
positive regulation of mitotic cell cycle phase transition
nerve development
neural crest cell development
central nervous system neuron development
mesenchymal cell development
stem cell development
neural crest cell differentiation
positive regulation of cell cycle phase transition