PIAS3

Gene Information

Official Symbol: PIAS3
Official Name: protein inhibitor of activated STAT 3
Aliases and Previous Symbols: N/A
Entrez ID: 10401
UniProt: Q9Y6X2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376). {ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:9388184}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3907
Expression level (log2 read counts): 4.95

Expression Distribution

TNFSF11-mediated signaling pathway
SUMO ligase activity
negative regulation of protein sumoylation
positive regulation of protein sumoylation
positive regulation of membrane potential
SUMO transferase activity
regulation of protein sumoylation
negative regulation of osteoclast differentiation
potassium channel regulator activity
negative regulation of myeloid leukocyte differentiation
RNA polymerase II transcription factor binding
regulation of osteoclast differentiation
protein sumoylation
negative regulation of myeloid cell differentiation
transcription coregulator activity
negative regulation of protein modification by small protein conjugation or removal
negative regulation of leukocyte differentiation
protein N-terminus binding
regulation of myeloid leukocyte differentiation
tumor necrosis factor-mediated signaling pathway
positive regulation of protein modification by small protein conjugation or removal
negative regulation of hemopoiesis
protein C-terminus binding
regulation of myeloid cell differentiation
regulation of protein modification by small protein conjugation or removal
cellular response to tumor necrosis factor
response to tumor necrosis factor
synapse
regulation of leukocyte differentiation
peptidyl-lysine modification
enzyme binding
nuclear speck
dendrite
regulation of membrane potential
negative regulation of immune system process
regulation of hemopoiesis
negative regulation of protein modification process
cytokine-mediated signaling pathway
negative regulation of cell differentiation
protein modification by small protein conjugation