PIEZO2

Entrez Summary: The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014].
UniProt Summary: Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light- touch mechanosensation. {ECO:0000250|UniProtKB:Q8CD54}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

mechanosensitive ion channel activity
cation channel activity
detection of mechanical stimulus involved in sensory perception
detection of mechanical stimulus
cellular response to mechanical stimulus
detection of external stimulus
detection of abiotic stimulus
sensory perception of mechanical stimulus
response to mechanical stimulus
cellular response to environmental stimulus
cellular response to abiotic stimulus
cellular response to external stimulus
regulation of membrane potential
detection of stimulus involved in sensory perception
cation transmembrane transport
detection of stimulus
cation transport
ion transmembrane transport
sensory perception
response to abiotic stimulus
transmembrane transport
ion transport
nervous system process
system process