PIK3R3 [The Human Chemical-Genetic Interaction Map Project]

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======= PIK3R3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIK3R3
  * **<color #00a2e8>Official Name</color>**: phosphoinositide-3-kinase regulatory subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8503|8503]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92569|Q92569]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIK3R3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIK3R3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606076|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|1-phosphatidylinositol-3-kinase activity|
|1-phosphatidylinositol-3-kinase regulator activity|
|phosphatidylinositol-3-phosphate biosynthetic process|
|phosphatidylinositol 3-kinase complex|
|cell migration involved in sprouting angiogenesis|
|blood vessel endothelial cell migration|
|protein kinase B signaling|
|phosphotyrosine residue binding|
|phosphatidylinositol phosphorylation|
|regulation of phosphatidylinositol 3-kinase activity|
|sprouting angiogenesis|
|regulation of lipid kinase activity|
|lipid phosphorylation|
|endothelial cell migration|
|epithelial cell migration|
|regulation of phospholipid metabolic process|
|epithelium migration|
|insulin receptor signaling pathway|
|tissue migration|
|phosphatidylinositol biosynthetic process|
|cellular response to insulin stimulus|
|phosphatidylinositol metabolic process|
|ameboidal-type cell migration|
|lipid modification|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|response to insulin|
|phospholipid biosynthetic process|
|cellular response to peptide hormone stimulus|
|glycerophospholipid metabolic process|
|angiogenesis|
|cellular response to peptide|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|response to peptide hormone|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|response to peptide|
|blood vessel development|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|organophosphate biosynthetic process|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|lipid biosynthetic process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|tube morphogenesis|
|cellular response to nitrogen compound|
|enzyme linked receptor protein signaling pathway|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cell motility|
|cellular lipid metabolic process|
|cell migration|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|locomotion|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.04|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.99|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.75|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.83|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.86|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.91|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.37|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11292
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIK3R3 Expression in NALM6 Cells: 6.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>