PIK3R3

Entrez Summary: Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016].
UniProt Summary: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lead acetate 2000μM R08 exp498 no dilution day6	-2.04
TNF-alpha 44ng/ml R08 exp533	-1.99
UMK57 0.6μM R03 exp107	1.75
DABN 2μM R00 exp16	1.83
Metformin 40μM R03 exp132	1.86
Alpha-Amanitin 0.5μM R00 exp5	1.91
Taxol 0.004μM R03 exp103	2.37
Nocodazole 0.02μM R00 exp23	2.42

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

1-phosphatidylinositol-3-kinase activity
1-phosphatidylinositol-3-kinase regulator activity
phosphatidylinositol-3-phosphate biosynthetic process
phosphatidylinositol 3-kinase complex
cell migration involved in sprouting angiogenesis
blood vessel endothelial cell migration
protein kinase B signaling
phosphotyrosine residue binding
phosphatidylinositol phosphorylation
regulation of phosphatidylinositol 3-kinase activity
sprouting angiogenesis
regulation of lipid kinase activity
lipid phosphorylation
endothelial cell migration
epithelial cell migration
regulation of phospholipid metabolic process
epithelium migration
insulin receptor signaling pathway
tissue migration
phosphatidylinositol biosynthetic process
cellular response to insulin stimulus
phosphatidylinositol metabolic process
ameboidal-type cell migration
lipid modification
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
response to insulin
phospholipid biosynthetic process
cellular response to peptide hormone stimulus
glycerophospholipid metabolic process
angiogenesis
cellular response to peptide
phospholipid metabolic process
glycerolipid metabolic process
response to peptide hormone
regulation of lipid metabolic process
blood vessel morphogenesis
response to peptide
blood vessel development
positive regulation of cell migration