PKP2

Gene Information

Official Symbol: PKP2
Official Name: plakophilin 2
Aliases and Previous Symbols: N/A
Entrez ID: 5318
UniProt: Q99959
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008].
UniProt Summary: May play a role in junctional plaques. {ECO:0000269|PubMed:22781308}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11047
Expression level (log2 read counts): 1.96

Expression Distribution

Screen	Score
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-1.84
Milciclib 2μM R08 exp502	1.75

desmosome assembly
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
maintenance of animal organ identity
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
adherens junction maintenance
intermediate filament bundle assembly
cardiac muscle cell-cardiac muscle cell adhesion
desmosome organization
alpha-catenin binding
intermediate filament binding
messenger ribonucleoprotein complex
bundle of His cell to Purkinje myocyte communication
regulation of ventricular cardiac muscle cell action potential
cell junction maintenance
cell communication by electrical coupling involved in cardiac conduction
cell communication by electrical coupling
ventricular cardiac muscle cell action potential
intermediate filament organization
desmosome
cell-cell signaling involved in cardiac conduction
regulation of cardiac muscle cell action potential
positive regulation of sodium ion transport
sodium channel regulator activity
heterotypic cell-cell adhesion
regulation of heart rate by cardiac conduction
regulation of cardiac muscle cell contraction
cardiac muscle cell action potential involved in contraction
cardiac muscle cell contraction
regulation of actin filament-based movement
cell communication involved in cardiac conduction
intercalated disc
cellular component maintenance
molecular adaptor activity
ventricular cardiac muscle tissue morphogenesis
cardiac muscle cell action potential
regulation of action potential
intermediate filament cytoskeleton organization
intermediate filament-based process
protein kinase C binding
ventricular cardiac muscle tissue development