PLA2G10 [The Human Chemical-Genetic Interaction Map Project]

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======= PLA2G10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLA2G10
  * **<color #00a2e8>Official Name</color>**: phospholipase A2 group X
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8399|8399]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15496|O15496]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLA2G10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLA2G10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603603|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine. {ECO:0000269|PubMed:12161451, ECO:0000269|PubMed:9188469}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Phospholip A2 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lysophospholipid transport|
|negative regulation of cholesterol efflux|
|positive regulation of arachidonic acid secretion|
|regulation of arachidonic acid secretion|
|positive regulation of prostaglandin secretion|
|regulation of prostaglandin secretion|
|negative regulation of cholesterol transport|
|negative regulation of sterol transport|
|positive regulation of icosanoid secretion|
|calcium-dependent phospholipase A2 activity|
|positive regulation of macrophage derived foam cell differentiation|
|phospholipase activity|
|phosphatidylinositol acyl-chain remodeling|
|phosphatidylglycerol acyl-chain remodeling|
|positive regulation of fatty acid transport|
|regulation of icosanoid secretion|
|positive regulation of lipid storage|
|phosphatidylserine acyl-chain remodeling|
|regulation of cholesterol efflux|
|arachidonate transport|
|arachidonic acid secretion|
|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|
|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|
|phosphatidylethanolamine acyl-chain remodeling|
|negative regulation of lipid transport|
|regulation of fatty acid transport|
|phosphatidylcholine acyl-chain remodeling|
|icosanoid secretion|
|phospholipase A2 activity|
|regulation of macrophage derived foam cell differentiation|
|phosphatidylglycerol metabolic process|
|phosphatidylserine metabolic process|
|icosanoid transport|
|fatty acid derivative transport|
|positive regulation of organic acid transport|
|phosphatidic acid biosynthetic process|
|negative regulation of lipid localization|
|phosphatidic acid metabolic process|
|regulation of lipid storage|
|regulation of cholesterol transport|
|regulation of sterol transport|
|positive regulation of anion transport|
|regulation of macrophage activation|
|arachidonic acid metabolic process|
|regulation of organic acid transport|
|long-chain fatty acid transport|
|positive regulation of lipid transport|
|carbohydrate derivative transport|
|fatty acid transport|
|phosphatidylcholine metabolic process|
|cholesterol homeostasis|
|sterol homeostasis|
|acid secretion|
|positive regulation of lipid localization|
|phospholipid transport|
|regulation of anion transport|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|phospholipid binding|
|unsaturated fatty acid metabolic process|
|regulation of lipid transport|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|organophosphate ester transport|
|lipid homeostasis|
|monocarboxylic acid transport|
|regulation of lipid localization|
|negative regulation of DNA-binding transcription factor activity|
|fatty acid derivative metabolic process|
|phosphatidylinositol metabolic process|
|ammonium ion metabolic process|
|cellular modified amino acid metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|axon guidance|
|neuron projection guidance|
|positive regulation of ion transport|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|lipid catabolic process|
|glycerophospholipid metabolic process|
|lipid localization|
|fatty acid metabolic process|
|axonogenesis|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|axon development|
|regulation of DNA-binding transcription factor activity|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|organic anion transport|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|cell projection morphogenesis|
|cell part morphogenesis|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|lipid biosynthetic process|
|anion transport|
|regulation of leukocyte activation|
|regulation of cell activation|
|neuron projection development|
|regulation of ion transport|
|calcium ion binding|
|cell morphogenesis|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|positive regulation of cell differentiation|
|positive regulation of transport|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|neuron differentiation|
|organic acid metabolic process|
|response to cytokine|
|chemical homeostasis|
|secretion|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|lipid metabolic process|
|locomotion|
|positive regulation of developmental process|
|ion transport|
|generation of neurons|
|movement of cell or subcellular component|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|regulation of cell differentiation|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 438/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|17/28|
|blood|13/28|
|bone|16/26|
|breast|14/33|
|central nervous system|33/56|
|cervix|2/4|
|colorectal|8/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|11/16|
|kidney|12/21|
|liver|14/20|
|lung|44/75|
|lymphocyte|5/16|
|ovary|14/26|
|pancreas|16/24|
|peripheral nervous system|10/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|16/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|19/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7974
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLA2G10 Expression in NALM6 Cells: 0.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>