PLA2G10
Gene Information
- Official Symbol: PLA2G10
- Official Name: phospholipase A2 group X
- Aliases and Previous Symbols: N/A
- Entrez ID: 8399
- UniProt: O15496
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine. {ECO:0000269|PubMed:12161451, ECO:0000269|PubMed:9188469}.
Pfam Domains GO Terms
Pfam Domains
| Phospholip A2 1 |
GO Terms
| lysophospholipid transport |
| negative regulation of cholesterol efflux |
| positive regulation of arachidonic acid secretion |
| regulation of arachidonic acid secretion |
| positive regulation of prostaglandin secretion |
| regulation of prostaglandin secretion |
| negative regulation of cholesterol transport |
| negative regulation of sterol transport |
| positive regulation of icosanoid secretion |
| calcium-dependent phospholipase A2 activity |
| positive regulation of macrophage derived foam cell differentiation |
| phospholipase activity |
| phosphatidylinositol acyl-chain remodeling |
| phosphatidylglycerol acyl-chain remodeling |
| positive regulation of fatty acid transport |
| regulation of icosanoid secretion |
| positive regulation of lipid storage |
| phosphatidylserine acyl-chain remodeling |
| regulation of cholesterol efflux |
| arachidonate transport |
| arachidonic acid secretion |
| phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) |
| phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) |
| phosphatidylethanolamine acyl-chain remodeling |
| negative regulation of lipid transport |
| regulation of fatty acid transport |
| phosphatidylcholine acyl-chain remodeling |
| icosanoid secretion |
| phospholipase A2 activity |
| regulation of macrophage derived foam cell differentiation |
| phosphatidylglycerol metabolic process |
| phosphatidylserine metabolic process |
| icosanoid transport |
| fatty acid derivative transport |
| positive regulation of organic acid transport |
| phosphatidic acid biosynthetic process |
| negative regulation of lipid localization |
| phosphatidic acid metabolic process |
| regulation of lipid storage |
| regulation of cholesterol transport |
| regulation of sterol transport |
| positive regulation of anion transport |
| regulation of macrophage activation |
| arachidonic acid metabolic process |
| regulation of organic acid transport |
| long-chain fatty acid transport |
| positive regulation of lipid transport |
| carbohydrate derivative transport |
| fatty acid transport |
| phosphatidylcholine metabolic process |
| cholesterol homeostasis |
| sterol homeostasis |
| acid secretion |
| positive regulation of lipid localization |
| phospholipid transport |
| regulation of anion transport |
| response to leukemia inhibitory factor |
| cellular response to leukemia inhibitory factor |
| phospholipid binding |
| unsaturated fatty acid metabolic process |
| regulation of lipid transport |
| icosanoid metabolic process |
| long-chain fatty acid metabolic process |
| organophosphate ester transport |
| lipid homeostasis |
| monocarboxylic acid transport |
| regulation of lipid localization |
| negative regulation of DNA-binding transcription factor activity |
| fatty acid derivative metabolic process |
| phosphatidylinositol metabolic process |
| ammonium ion metabolic process |
| cellular modified amino acid metabolic process |
| glycerophospholipid biosynthetic process |
| glycerolipid biosynthetic process |
| phospholipid biosynthetic process |
| axon guidance |
| neuron projection guidance |
| positive regulation of ion transport |
| carboxylic acid transport |
| organic acid transport |
| lipid transport |
| lipid catabolic process |
| glycerophospholipid metabolic process |
| lipid localization |
| fatty acid metabolic process |
| axonogenesis |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| axon development |
| regulation of DNA-binding transcription factor activity |
| cell morphogenesis involved in neuron differentiation |
| positive regulation of secretion |
| organic anion transport |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| negative regulation of transport |
| cell projection morphogenesis |
| cell part morphogenesis |
| monocarboxylic acid metabolic process |
| organophosphate biosynthetic process |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| lipid biosynthetic process |
| anion transport |
| regulation of leukocyte activation |
| regulation of cell activation |
| neuron projection development |
| regulation of ion transport |
| calcium ion binding |
| cell morphogenesis |
| regulation of secretion |
| neuron development |
| cellular component morphogenesis |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| cellular lipid metabolic process |
| positive regulation of cell differentiation |
| positive regulation of transport |
| oxoacid metabolic process |
| cellular response to cytokine stimulus |
| neuron differentiation |
| organic acid metabolic process |
| response to cytokine |
| chemical homeostasis |
| secretion |
| plasma membrane bounded cell projection organization |
| negative regulation of molecular function |
| cell projection organization |
| lipid metabolic process |
| locomotion |
| positive regulation of developmental process |
| ion transport |
| generation of neurons |
| movement of cell or subcellular component |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| homeostatic process |
| cell development |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| small molecule metabolic process |
| organic substance catabolic process |
| regulation of cell differentiation |
| regulation of transport |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 438/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 17/28 |
| blood | 13/28 |
| bone | 16/26 |
| breast | 14/33 |
| central nervous system | 33/56 |
| cervix | 2/4 |
| colorectal | 8/17 |
| esophagus | 7/13 |
| fibroblast | 0/1 |
| gastric | 11/16 |
| kidney | 12/21 |
| liver | 14/20 |
| lung | 44/75 |
| lymphocyte | 5/16 |
| ovary | 14/26 |
| pancreas | 16/24 |
| peripheral nervous system | 10/16 |
| plasma cell | 9/15 |
| prostate | 1/1 |
| skin | 16/24 |
| soft tissue | 6/9 |
| thyroid | 1/2 |
| upper aerodigestive | 8/22 |
| urinary tract | 19/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 7974
- Expression level (log2 read counts): 0.25
Expression Distribution
PLA2G10 Expression in NALM6 Cells: 0.25
