PLA2G3

Entrez Summary: N/A
UniProt Summary: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl- phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1- palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis. {ECO:0000269|PubMed:12522102, ECO:0000269|PubMed:20393563}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sperm axoneme assembly
lipoxygenase pathway
calcium-dependent phospholipase A2 activity
mast cell activation involved in immune response
mast cell degranulation
acrosome assembly
phosphatidylglycerol acyl-chain remodeling
mast cell mediated immunity
mast cell granule
mast cell activation
arachidonic acid secretion
arachidonate transport
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phosphatidylethanolamine acyl-chain remodeling
phosphatidylcholine acyl-chain remodeling
icosanoid secretion
phosphatidylglycerol metabolic process
icosanoid transport
fatty acid derivative transport
secretory granule organization
lysosome localization
long-chain fatty acid transport
axoneme assembly
flagellated sperm motility
sperm motility
fatty acid transport
phosphatidylcholine metabolic process
acid secretion
microtubule bundle formation
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
cellular component assembly involved in morphogenesis
icosanoid metabolic process
monocarboxylic acid transport
centriole
spermatid development
spermatid differentiation
fatty acid derivative metabolic process
ammonium ion metabolic process