PLA2G4B

Entrez Summary: N/A
UniProt Summary: Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine. {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:16617059}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

C2
PLA2 B

parturition
calcium-dependent phospholipase A2 activity
phosphatidylglycerol acyl-chain remodeling
glycerophospholipid catabolic process
phosphatidylserine acyl-chain remodeling
lysophospholipase activity
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phosphatidylethanolamine acyl-chain remodeling
phosphatidylcholine acyl-chain remodeling
phospholipase A2 activity
phosphatidylglycerol metabolic process
phosphatidylserine metabolic process
phospholipid catabolic process
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
glycerolipid catabolic process
IRE1-mediated unfolded protein response
calcium-dependent phospholipid binding
arachidonic acid metabolic process
phosphatidylcholine metabolic process
endoplasmic reticulum unfolded protein response
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
cellular response to unfolded protein
organophosphate catabolic process
calcium-mediated signaling
cellular response to topologically incorrect protein
early endosome membrane
response to unfolded protein
fatty acid derivative metabolic process
response to topologically incorrect protein
ammonium ion metabolic process
cellular lipid catabolic process
cellular modified amino acid metabolic process
glycerophospholipid biosynthetic process
multi-multicellular organism process
glycerolipid biosynthetic process
phospholipid biosynthetic process