PLA2G7

Entrez Summary: The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009].
UniProt Summary: Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

plasma lipoprotein particle oxidation
1-alkyl-2-acetylglycerophosphocholine esterase activity
platelet activating factor metabolic process
calcium-independent phospholipase A2 activity
hydrolase activity, acting on ester bonds
low-density lipoprotein particle remodeling
low-density lipoprotein particle
positive regulation of monocyte chemotaxis
positive regulation of mononuclear cell migration
regulation of monocyte chemotaxis
plasma lipoprotein particle remodeling
protein-lipid complex remodeling
protein-containing complex remodeling
plasma lipoprotein particle organization
regulation of mononuclear cell migration
protein-lipid complex subunit organization
regulation of plasma lipoprotein particle levels
lipid oxidation
positive regulation of leukocyte chemotaxis
phospholipid binding
regulation of leukocyte chemotaxis
positive regulation of leukocyte migration
positive regulation of chemotaxis
positive regulation of inflammatory response
ammonium ion metabolic process
regulation of leukocyte migration
lipid modification
regulation of chemotaxis
lipid catabolic process
glycerophospholipid metabolic process
regulation of inflammatory response
phospholipid metabolic process
glycerolipid metabolic process
extracellular structure organization
positive regulation of defense response
drug metabolic process
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion