PLAGL1

Gene Information
  • Official Symbol: PLAGL1
  • Official Name: PLAG1 like zinc finger 1
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 5325
  • UniProt: Q9UM63
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]. COMPLETENESS: complete on the 3' end.
  • UniProt Summary: N/A

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 4929
  • Expression level (log2 read counts): -0.45

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1