PLCB2 [The Human Chemical-Genetic Interaction Map Project]

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======= PLCB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLCB2
  * **<color #00a2e8>Official Name</color>**: phospholipase C beta 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5330|5330]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q00722|Q00722]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLCB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLCB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604114|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:1644792}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PLC-beta C|
|efhand like|
|C2|
|PI-PLC-Y|
|PI-PLC-X|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phospholipase C activity|
|inositol trisphosphate biosynthetic process|
|inositol trisphosphate metabolic process|
|phosphatidylinositol phospholipase C activity|
|inositol phosphate biosynthetic process|
|activation of phospholipase C activity|
|Wnt signaling pathway, calcium modulating pathway|
|positive regulation of phospholipase C activity|
|sensory perception of bitter taste|
|regulation of phospholipase C activity|
|release of sequestered calcium ion into cytosol|
|negative regulation of sequestering of calcium ion|
|inositol phosphate metabolic process|
|positive regulation of phospholipase activity|
|polyol biosynthetic process|
|calcium ion transmembrane import into cytosol|
|sensory perception of taste|
|phosphatidylinositol-mediated signaling|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|calcium ion transport into cytosol|
|inositol lipid-mediated signaling|
|cytosolic calcium ion transport|
|regulation of lipase activity|
|polyol metabolic process|
|alcohol biosynthetic process|
|regulation of sequestering of calcium ion|
|non-canonical Wnt signaling pathway|
|organic hydroxy compound biosynthetic process|
|calcium ion transmembrane transport|
|calcium ion transport|
|positive regulation of cytosolic calcium ion concentration|
|divalent metal ion transport|
|lipid catabolic process|
|divalent inorganic cation transport|
|alcohol metabolic process|
|regulation of cytosolic calcium ion concentration|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|phospholipid metabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|organic hydroxy compound metabolic process|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|organophosphate biosynthetic process|
|sensory perception of chemical stimulus|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|small molecule biosynthetic process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cation transport|
|organophosphate metabolic process|
|cellular homeostasis|
|ion transmembrane transport|
|cellular lipid metabolic process|
|sensory perception|
|chemical homeostasis|
|cell-cell signaling|
|lipid metabolic process|
|transmembrane transport|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|ion transport|
|nervous system process|
|positive regulation of catalytic activity|
|homeostatic process|
|intracellular signal transduction|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|establishment of localization in cell|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.8|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.75|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.7|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3654
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLCB2 Expression in NALM6 Cells: 1.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>