PLCB2

Entrez Summary: The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017].
UniProt Summary: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:1644792}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
A-196 10μM R03 exp114	-1.8
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.75
Tunicamycin 0.04μM R07 exp418	-1.7
Pyridostatin 4μM R05 exp240	1.83

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phospholipase C activity
inositol trisphosphate biosynthetic process
inositol trisphosphate metabolic process
phosphatidylinositol phospholipase C activity
inositol phosphate biosynthetic process
activation of phospholipase C activity
Wnt signaling pathway, calcium modulating pathway
positive regulation of phospholipase C activity
sensory perception of bitter taste
regulation of phospholipase C activity
release of sequestered calcium ion into cytosol
negative regulation of sequestering of calcium ion
inositol phosphate metabolic process
positive regulation of phospholipase activity
polyol biosynthetic process
calcium ion transmembrane import into cytosol
sensory perception of taste
phosphatidylinositol-mediated signaling
positive regulation of lipase activity
regulation of phospholipase activity
calcium ion transport into cytosol
inositol lipid-mediated signaling
cytosolic calcium ion transport
regulation of lipase activity
polyol metabolic process
alcohol biosynthetic process
regulation of sequestering of calcium ion
non-canonical Wnt signaling pathway
organic hydroxy compound biosynthetic process
calcium ion transmembrane transport
calcium ion transport
positive regulation of cytosolic calcium ion concentration
divalent metal ion transport
lipid catabolic process
divalent inorganic cation transport
alcohol metabolic process
regulation of cytosolic calcium ion concentration
Wnt signaling pathway
cell-cell signaling by wnt
phospholipid metabolic process