PLCD1

Entrez Summary: This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
UniProt Summary: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GTPase activating protein binding
inositol trisphosphate biosynthetic process
labyrinthine layer blood vessel development
inositol trisphosphate metabolic process
phosphatidylinositol phospholipase C activity
inositol phosphate biosynthetic process
placenta blood vessel development
labyrinthine layer development
inositol phosphate metabolic process
polyol biosynthetic process
phosphatidylinositol-4,5-bisphosphate binding
embryonic placenta development
polyol metabolic process
alcohol biosynthetic process
placenta development
organic hydroxy compound biosynthetic process
lipid catabolic process
angiogenesis
alcohol metabolic process
phospholipid metabolic process
in utero embryonic development
blood vessel morphogenesis
reproductive structure development
reproductive system development
embryonic organ development
organic hydroxy compound metabolic process
blood vessel development
vasculature development
cardiovascular system development
organophosphate biosynthetic process
small molecule biosynthetic process
chordate embryonic development
embryo development ending in birth or egg hatching
tube morphogenesis
developmental process involved in reproduction
calcium ion binding
tube development
circulatory system development
organophosphate metabolic process
anatomical structure formation involved in morphogenesis