PLCD3

Entrez Summary: N/A
UniProt Summary: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

Screen	Score
SGC0946 7μM R03 exp151	-1.96
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.7

PI-PLC-X
efhand like

inositol trisphosphate biosynthetic process
labyrinthine layer blood vessel development
inositol trisphosphate metabolic process
phosphatidylinositol phospholipase C activity
inositol phosphate biosynthetic process
placenta blood vessel development
labyrinthine layer development
cleavage furrow
inositol phosphate metabolic process
polyol biosynthetic process
embryonic placenta development
polyol metabolic process
alcohol biosynthetic process
placenta development
organic hydroxy compound biosynthetic process
lipid catabolic process
angiogenesis
alcohol metabolic process
in utero embryonic development
blood vessel morphogenesis
reproductive structure development
reproductive system development
embryonic organ development
organic hydroxy compound metabolic process
blood vessel development
vasculature development
cardiovascular system development
organophosphate biosynthetic process
small molecule biosynthetic process
chordate embryonic development
embryo development ending in birth or egg hatching
tube morphogenesis
developmental process involved in reproduction
tube development
circulatory system development
organophosphate metabolic process
anatomical structure formation involved in morphogenesis
embryo development
lipid metabolic process
reproductive process