PLCD4

Entrez Summary: N/A
UniProt Summary: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. {ECO:0000269|PubMed:15140260}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

inositol trisphosphate biosynthetic process
inositol trisphosphate metabolic process
acrosome reaction
phosphatidylinositol phospholipase C activity
inositol phosphate biosynthetic process
inositol phosphate metabolic process
polyol biosynthetic process
polyol metabolic process
alcohol biosynthetic process
single fertilization
phosphatidylinositol metabolic process
fertilization
organic hydroxy compound biosynthetic process
nuclear membrane
lipid catabolic process
glycerophospholipid metabolic process
alcohol metabolic process
phospholipid metabolic process
glycerolipid metabolic process
organic hydroxy compound metabolic process
organophosphate biosynthetic process
small molecule biosynthetic process
calcium ion binding
sexual reproduction
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
multi-organism reproductive process
lipid metabolic process
reproductive process
reproduction
intracellular signal transduction
small molecule metabolic process
organic substance catabolic process