PLCZ1 [The Human Chemical-Genetic Interaction Map Project]

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======= PLCZ1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLCZ1
  * **<color #00a2e8>Official Name</color>**: phospholipase C zeta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=89869|89869]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86YW0|Q86YW0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLCZ1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLCZ1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608075|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. {ECO:0000250|UniProtKB:Q8K4D7, ECO:0000269|PubMed:12416999, ECO:0000269|PubMed:14697805, ECO:0000269|PubMed:15579586, ECO:0000269|PubMed:26721930, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
|PI-PLC-X|
|PI-PLC-Y|
|efhand like|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cytosolic calcium ion concentration involved in egg activation|
|egg activation|
|pronucleus|
|sperm head|
|inositol trisphosphate biosynthetic process|
|phosphatidylinositol-5-phosphate binding|
|inositol trisphosphate metabolic process|
|phosphatidylinositol phospholipase C activity|
|inositol phosphate biosynthetic process|
|phosphatidylinositol-3-phosphate binding|
|inositol phosphate metabolic process|
|polyol biosynthetic process|
|phosphatidylinositol-4,5-bisphosphate binding|
|polyol metabolic process|
|alcohol biosynthetic process|
|single fertilization|
|fertilization|
|organic hydroxy compound biosynthetic process|
|calcium ion transport|
|positive regulation of cytosolic calcium ion concentration|
|divalent metal ion transport|
|lipid catabolic process|
|divalent inorganic cation transport|
|alcohol metabolic process|
|regulation of cytosolic calcium ion concentration|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|organic hydroxy compound metabolic process|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|organophosphate biosynthetic process|
|cellular metal ion homeostasis|
|small molecule biosynthetic process|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|perinuclear region of cytoplasm|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|sexual reproduction|
|nucleolus|
|organophosphate metabolic process|
|cellular homeostasis|
|multi-organism reproductive process|
|cell activation|
|chemical homeostasis|
|lipid metabolic process|
|ion transport|
|reproductive process|
|reproduction|
|homeostatic process|
|intracellular signal transduction|
|small molecule metabolic process|
|organic substance catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.82|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.7|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.74|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.8|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13533
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLCZ1 Expression in NALM6 Cells: -1.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>