PLCZ1

Gene Information

Official Symbol: PLCZ1
Official Name: phospholipase C zeta 1
Aliases and Previous Symbols: N/A
Entrez ID: 89869
UniProt: Q86YW0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
UniProt Summary: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. {ECO:0000250|UniProtKB:Q8K4D7, ECO:0000269|PubMed:12416999, ECO:0000269|PubMed:14697805, ECO:0000269|PubMed:15579586, ECO:0000269|PubMed:26721930, ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trimetrexate 0.03μM R08 exp535	-1.82
GSK626616 14μM R08 exp485	-1.7
SGC0649 7μM R03 exp150	1.74
2-Methoxyestradiol 0.2μM R01 exp40	1.8
Vinblastine 0.002μM R01 exp60	2.17

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13533
Expression level (log2 read counts): -1.92

Expression Distribution

C2
PI-PLC-X
PI-PLC-Y
efhand like

positive regulation of cytosolic calcium ion concentration involved in egg activation
egg activation
pronucleus
sperm head
inositol trisphosphate biosynthetic process
phosphatidylinositol-5-phosphate binding
inositol trisphosphate metabolic process
phosphatidylinositol phospholipase C activity
inositol phosphate biosynthetic process
phosphatidylinositol-3-phosphate binding
inositol phosphate metabolic process
polyol biosynthetic process
phosphatidylinositol-4,5-bisphosphate binding
polyol metabolic process
alcohol biosynthetic process
single fertilization
fertilization
organic hydroxy compound biosynthetic process
calcium ion transport
positive regulation of cytosolic calcium ion concentration
divalent metal ion transport
lipid catabolic process
divalent inorganic cation transport
alcohol metabolic process
regulation of cytosolic calcium ion concentration
cellular calcium ion homeostasis
calcium ion homeostasis
organic hydroxy compound metabolic process
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
organophosphate biosynthetic process
cellular metal ion homeostasis
small molecule biosynthetic process
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
perinuclear region of cytoplasm
cation homeostasis
inorganic ion homeostasis