PLXNA2

Entrez Summary: N/A
UniProt Summary: Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity). {ECO:0000250, ECO:0000269|PubMed:10520995}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cerebellar granule cell precursor tangential migration
hindbrain tangential cell migration
limb bud formation
semaphorin receptor complex
semaphorin-plexin signaling pathway involved in axon guidance
semaphorin receptor activity
semaphorin-plexin signaling pathway involved in neuron projection guidance
cell migration in hindbrain
pharyngeal system development
centrosome localization
microtubule organizing center localization
semaphorin-plexin signaling pathway
somitogenesis
somite development
positive regulation of axonogenesis
segmentation
limb morphogenesis
appendage morphogenesis
hindbrain development
regulation of cell shape
positive regulation of cell morphogenesis involved in differentiation
neural tube development
appendage development
limb development
regulation of axonogenesis
anterior/posterior pattern specification
axon guidance
neuron projection guidance
negative regulation of cell adhesion
positive regulation of neuron projection development
regulation of cell morphogenesis involved in differentiation
regionalization
positive regulation of neuron differentiation
axonogenesis
positive regulation of cell projection organization
axon development
cell morphogenesis involved in neuron differentiation
pattern specification process
positive regulation of neurogenesis
neuron projection morphogenesis