PM20D1 [The Human Chemical-Genetic Interaction Map Project]

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======= PM20D1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PM20D1
  * **<color #00a2e8>Official Name</color>**: peptidase M20 domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=148811|148811]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6GTS8|Q6GTS8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PM20D1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PM20D1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617124|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Bidirectional N-fatty-acyl amino acid synthase/hydrolase that regulates the production of N-fatty-acyl amino acids. These metabolites are endogenous chemical uncouplers of mitochondrial respiration. In an UCP1-independent manner, maybe through interaction with mitochondrial transporters, they promote proton leakage into the mitochondrial matrix. Thereby, this secreted protein may indirectly regulate the bodily dissipation of chemical energy as heat through thermogenic respiration. {ECO:0000269|PubMed:27374330}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M20|
|M20 dimer|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular amide catabolic process|
|regulation of oxidative phosphorylation uncoupler activity|
|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|
|lyase activity|
|adaptive thermogenesis|
|regulation of proton transport|
|energy homeostasis|
|peptidase activity|
|negative regulation of neuron death|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|cellular amino acid metabolic process|
|regulation of neuron death|
|multicellular organismal homeostasis|
|regulation of cation transmembrane transport|
|cellular nitrogen compound catabolic process|
|regulation of ion transmembrane transport|
|amide biosynthetic process|
|regulation of transmembrane transport|
|regulation of ion transport|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|negative regulation of cell death|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|proteolysis|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|regulation of cell death|
|small molecule metabolic process|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7674
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PM20D1 Expression in NALM6 Cells: -0.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>