PM20D1

Entrez Summary: N/A
UniProt Summary: Bidirectional N-fatty-acyl amino acid synthase/hydrolase that regulates the production of N-fatty-acyl amino acids. These metabolites are endogenous chemical uncouplers of mitochondrial respiration. In an UCP1-independent manner, maybe through interaction with mitochondrial transporters, they promote proton leakage into the mitochondrial matrix. Thereby, this secreted protein may indirectly regulate the bodily dissipation of chemical energy as heat through thermogenic respiration. {ECO:0000269|PubMed:27374330}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Peptidase M20
M20 dimer

cellular amide catabolic process
regulation of oxidative phosphorylation uncoupler activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
lyase activity
adaptive thermogenesis
regulation of proton transport
energy homeostasis
peptidase activity
negative regulation of neuron death
regulation of transmembrane transporter activity
regulation of transporter activity
cellular amino acid metabolic process
regulation of neuron death
multicellular organismal homeostasis
regulation of cation transmembrane transport
cellular nitrogen compound catabolic process
regulation of ion transmembrane transport
amide biosynthetic process
regulation of transmembrane transport
regulation of ion transport
cellular amide metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
negative regulation of cell death
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
proteolysis
cellular nitrogen compound biosynthetic process
homeostatic process
regulation of cell death
small molecule metabolic process
cellular catabolic process
regulation of transport