PMEPA1

Gene Information

Official Symbol: PMEPA1
Official Name: prostate transmembrane protein, androgen induced 1
Aliases and Previous Symbols: N/A
Entrez ID: 56937
UniProt: Q969W9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
UniProt Summary: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). {ECO:0000269|PubMed:18703514, ECO:0000269|PubMed:20129061, ECO:0000269|PubMed:24627487}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15365
Expression level (log2 read counts): 3.8

Expression Distribution

negative regulation of SMAD protein complex assembly
regulation of SMAD protein complex assembly
negative regulation of pathway-restricted SMAD protein phosphorylation
R-SMAD binding
WW domain binding
androgen receptor signaling pathway
regulation of pathway-restricted SMAD protein phosphorylation
intracellular steroid hormone receptor signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
steroid hormone mediated signaling pathway
negative regulation of protein complex assembly
negative regulation of cellular response to growth factor stimulus
early endosome membrane
intracellular receptor signaling pathway
hormone-mediated signaling pathway
cellular response to steroid hormone stimulus
endosome membrane
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to growth factor stimulus
response to steroid hormone
negative regulation of protein phosphorylation
negative regulation of phosphorylation
regulation of protein complex assembly
cellular response to lipid
cellular response to organic cyclic compound
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
cellular response to hormone stimulus
Golgi membrane
intracellular membrane-bounded organelle
negative regulation of cellular component organization
response to lipid
response to hormone
response to organic cyclic compound
regulation of cellular component biogenesis