PMM1

Entrez Summary: N/A
UniProt Summary: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. {ECO:0000269|PubMed:16540464}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Epigallocatechin gallate 20μM R05 exp230	1.73
Ibrutinib 10μM R08 exp442	1.77
Fas-L 44ng/ml R08 exp482	1.84
Dihydrosphingosine 8μM R08 exp476	1.91
UM0131023 0.05μM R05 exp248	1.98
BAY-598 4μM R05 exp220	2.07
Citral 50μM R06 exp274	2.08
Amiloride 100μM R08 exp447	2.36
Calcipotriol 5μM R08 exp464	2.49

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PMM
Hydrolase 3

phosphomannomutase activity
GDP-mannose biosynthetic process
GDP-mannose metabolic process
mannose metabolic process
nucleotide-sugar biosynthetic process
nucleotide-sugar metabolic process
protein N-linked glycosylation
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
protein localization to endoplasmic reticulum
hexose metabolic process
monosaccharide metabolic process
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
protein targeting
neuronal cell body
glycoprotein metabolic process
establishment of protein localization to organelle
carbohydrate metabolic process
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
protein localization to organelle
intracellular protein transport
cellular response to cytokine stimulus
carbohydrate derivative metabolic process
nucleobase-containing compound biosynthetic process
response to cytokine
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization