PNPLA4 [The Human Chemical-Genetic Interaction Map Project]

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======= PNPLA4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PNPLA4
  * **<color #00a2e8>Official Name</color>**: patatin like phospholipase domain containing 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8228|8228]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41247|P41247]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PNPLA4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PNPLA4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300102|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the patatin-like family of phospholipases. The encoded enzyme has both triacylglycerol lipase and transacylase activities and may be involved in adipocyte triglyceride homeostasis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome Y. [provided by RefSeq, Feb 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Lipid hydrolase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Patatin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retinyl-palmitate esterase activity|
|triglyceride lipase activity|
|triglyceride catabolic process|
|acylglycerol catabolic process|
|neutral lipid catabolic process|
|retinol metabolic process|
|glycerolipid catabolic process|
|triglyceride metabolic process|
|primary alcohol metabolic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|retinoid metabolic process|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|isoprenoid metabolic process|
|cellular lipid catabolic process|
|hormone metabolic process|
|lipid catabolic process|
|alcohol metabolic process|
|glycerolipid metabolic process|
|organic hydroxy compound metabolic process|
|regulation of hormone levels|
|cellular lipid metabolic process|
|lipid metabolic process|
|mitochondrion|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.72|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.8|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17988
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PNPLA4 Expression in NALM6 Cells: 1.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>