PNPLA4

Entrez Summary: This gene encodes a member of the patatin-like family of phospholipases. The encoded enzyme has both triacylglycerol lipase and transacylase activities and may be involved in adipocyte triglyceride homeostasis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome Y. [provided by RefSeq, Feb 2010].
UniProt Summary: Lipid hydrolase.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

retinyl-palmitate esterase activity
triglyceride lipase activity
triglyceride catabolic process
acylglycerol catabolic process
neutral lipid catabolic process
retinol metabolic process
glycerolipid catabolic process
triglyceride metabolic process
primary alcohol metabolic process
acylglycerol metabolic process
neutral lipid metabolic process
retinoid metabolic process
diterpenoid metabolic process
terpenoid metabolic process
cellular hormone metabolic process
isoprenoid metabolic process
cellular lipid catabolic process
hormone metabolic process
lipid catabolic process
alcohol metabolic process
glycerolipid metabolic process
organic hydroxy compound metabolic process
regulation of hormone levels
cellular lipid metabolic process
lipid metabolic process
mitochondrion
small molecule metabolic process
organic substance catabolic process
cellular catabolic process