PNPO [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= PNPO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PNPO
  * **<color #00a2e8>Official Name</color>**: pyridoxamine 5'-phosphate oxidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55163|55163]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVS9|Q9NVS9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PNPO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PNPO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603287|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). {ECO:0000269|PubMed:12824491}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pyridox oxase 2|
|Pyridox oxidase|
|PNPOx C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pyridoxamine-phosphate oxidase activity|
|pyridoxine biosynthetic process|
|pyridoxal phosphate biosynthetic process|
|pyridoxine metabolic process|
|pyridoxal phosphate metabolic process|
|vitamin B6 biosynthetic process|
|vitamin B6 metabolic process|
|aldehyde biosynthetic process|
|water-soluble vitamin biosynthetic process|
|FMN binding|
|vitamin biosynthetic process|
|pyridine-containing compound biosynthetic process|
|pyridine-containing compound metabolic process|
|pyridoxal phosphate binding|
|cellular aldehyde metabolic process|
|water-soluble vitamin metabolic process|
|vitamin metabolic process|
|coenzyme biosynthetic process|
|organic hydroxy compound biosynthetic process|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|small molecule biosynthetic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|oxidation-reduction process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.17|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.98|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.88|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.79|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.05|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.08|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8116
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PNPO Expression in NALM6 Cells: 4.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>