PNPO

Entrez Summary: The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy. [provided by RefSeq, Oct 2008].
UniProt Summary: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). {ECO:0000269|PubMed:12824491}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
QNZ 0.01μM R05 exp241	-2.17
Phenformin 20μM R03 exp143	-1.98
Dynasore 10μM R04 exp180	-1.88
Rotenone 20μM R00 exp34	-1.79
Aminopterin 0.005μM R07 exp335	2.05
Dimethyloxaloylglycine 100μM R05 exp229	2.08
UM0125461 0.74μM R02 exp84	2.24

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

pyridoxamine-phosphate oxidase activity
pyridoxine biosynthetic process
pyridoxal phosphate biosynthetic process
pyridoxine metabolic process
pyridoxal phosphate metabolic process
vitamin B6 biosynthetic process
vitamin B6 metabolic process
aldehyde biosynthetic process
water-soluble vitamin biosynthetic process
FMN binding
vitamin biosynthetic process
pyridine-containing compound biosynthetic process
pyridine-containing compound metabolic process
pyridoxal phosphate binding
cellular aldehyde metabolic process
water-soluble vitamin metabolic process
vitamin metabolic process
coenzyme biosynthetic process
organic hydroxy compound biosynthetic process
cofactor biosynthetic process
coenzyme metabolic process
cofactor metabolic process
organic hydroxy compound metabolic process
drug metabolic process
organophosphate biosynthetic process
small molecule biosynthetic process
protein homodimerization activity
organophosphate metabolic process
oxidation-reduction process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process