POGZ

Entrez Summary: The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010].
UniProt Summary: Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms. {ECO:0000269|PubMed:20562864}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

DDE 1
HTH Tnp Tc5

kinetochore assembly
mitotic sister chromatid cohesion
kinetochore organization
RNA polymerase II core promoter sequence-specific DNA binding
centromere complex assembly
histone methyltransferase complex
sister chromatid cohesion
mitotic sister chromatid segregation
sister chromatid segregation
mitotic nuclear division
protein-DNA complex assembly
nuclear chromosome segregation
nuclear chromatin
protein-DNA complex subunit organization
chromosome segregation
nuclear division
organelle fission
cell division
mitotic cell cycle process
mitotic cell cycle
organelle assembly
cellular protein-containing complex assembly
cell cycle process
chromosome organization
cell cycle
protein-containing complex assembly
DNA-binding transcription factor activity, RNA polymerase II-specific
protein-containing complex subunit organization