POMT1

Entrez Summary: The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS) and limb-girdle muscular dystrophy type 2K (LGMD2K). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
HMS-I2 5μM R06 exp287	-1.87
Pimelic-diphenylamide-106 5μM R00 exp28	-1.81

PMT
MIR

positive regulation of protein O-linked glycosylation
regulation of protein O-linked glycosylation
positive regulation of protein glycosylation
dolichyl-phosphate-mannose-protein mannosyltransferase activity
regulation of protein glycosylation
protein O-linked mannosylation
positive regulation of glycoprotein biosynthetic process
mannosyltransferase activity
positive regulation of glycoprotein metabolic process
protein mannosylation
mannosylation
regulation of glycoprotein biosynthetic process
sarcoplasmic reticulum
regulation of glycoprotein metabolic process
acrosomal vesicle
protein O-linked glycosylation
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
extracellular matrix organization
extracellular structure organization
glycoprotein metabolic process
carbohydrate metabolic process
carbohydrate derivative biosynthetic process
endoplasmic reticulum membrane
endoplasmic reticulum
carbohydrate derivative metabolic process
positive regulation of protein modification process
organonitrogen compound biosynthetic process
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
regulation of protein modification process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of biosynthetic process