PON1

Entrez Summary: This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7. [provided by RefSeq, Aug 2017].
UniProt Summary: Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. {ECO:0000269|PubMed:10479665, ECO:0000269|PubMed:15772423}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SGL
Arylesterase

aryldialkylphosphatase activity
negative regulation of plasma lipoprotein oxidation
regulation of plasma lipoprotein oxidation
acyl-L-homoserine-lactone lactonohydrolase activity
response to fluoride
arylesterase activity
spherical high-density lipoprotein particle
positive regulation of cholesterol efflux
lipoxygenase pathway
high-density lipoprotein particle
positive regulation of sterol transport
regulation of cholesterol efflux
positive regulation of cholesterol transport
regulation of cholesterol transport
regulation of sterol transport
positive regulation of lipid transport
phosphatidylcholine metabolic process
positive regulation of lipid localization
response to fatty acid
phospholipid binding
regulation of lipid transport
positive regulation of transporter activity
icosanoid metabolic process
cholesterol metabolic process
organophosphate catabolic process
secondary alcohol metabolic process
sterol metabolic process
regulation of lipid localization
blood microparticle
fatty acid derivative metabolic process
positive regulation of binding
ammonium ion metabolic process
steroid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
regulation of transporter activity
glycerophospholipid metabolic process
dephosphorylation
alcohol metabolic process
fatty acid metabolic process