POU4F3

Entrez Summary: This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009].
UniProt Summary: Acts as a transcriptional activator (PubMed:18228599). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:18228599). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q63955, ECO:0000269|PubMed:18228599}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Homeobox
Pou

vestibulocochlear nerve development
retinal ganglion cell axon guidance
inner ear auditory receptor cell differentiation
hair cell differentiation
axon extension
neuroepithelial cell differentiation
neuron apoptotic process
cranial nerve development
neuron death
neuromuscular process controlling balance
inner ear receptor cell differentiation
mechanoreceptor differentiation
neuron projection extension
nerve development
developmental cell growth
cell growth
columnar/cuboidal epithelial cell differentiation
inner ear morphogenesis
neuromuscular process
developmental growth involved in morphogenesis
ear morphogenesis
sensory perception of sound
sensory perception of mechanical stimulus
inner ear development
ear development
visual perception
sensory perception of light stimulus
sensory organ morphogenesis
axon guidance
neuron projection guidance
embryonic organ morphogenesis
epidermal cell differentiation
axonogenesis
developmental growth
growth
axon development
epidermis development
cell morphogenesis involved in neuron differentiation
embryonic organ development
DNA-binding transcription activator activity, RNA polymerase II-specific