PPAPDC2

Entrez Summary: N/A
UniProt Summary: Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid. {ECO:0000269|PubMed:16464866}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lipid phosphatase activity
phospholipid dephosphorylation
cholesterol biosynthetic process
secondary alcohol biosynthetic process
sterol biosynthetic process
hydrolase activity
alcohol biosynthetic process
cholesterol metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
sterol metabolic process
organic hydroxy compound biosynthetic process
lipid modification
steroid metabolic process
dephosphorylation
alcohol metabolic process
organic hydroxy compound metabolic process
lipid biosynthetic process
small molecule biosynthetic process
cellular lipid metabolic process
lipid metabolic process
organic cyclic compound biosynthetic process
small molecule metabolic process