PPEF2

Entrez Summary: N/A
UniProt Summary: May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of peptidyl-threonine phosphorylation
mitogen-activated protein kinase kinase kinase binding
Hsp90 protein binding
Hsp70 protein binding
regulation of peptidyl-threonine phosphorylation
photoreceptor inner segment
photoreceptor outer segment
manganese ion binding
protein serine/threonine phosphatase activity
regulation of JUN kinase activity
iron ion binding
negative regulation of MAPK cascade
regulation of JNK cascade
protein dephosphorylation
visual perception
sensory perception of light stimulus
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
dephosphorylation
regulation of MAP kinase activity
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
regulation of protein serine/threonine kinase activity
detection of stimulus involved in sensory perception
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
detection of stimulus
calcium ion binding
regulation of cellular response to stress
regulation of MAPK cascade
regulation of protein kinase activity
regulation of kinase activity
sensory perception
regulation of transferase activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of signal transduction
negative regulation of cell communication