PPIF

Gene Information

Official Symbol: PPIF
Official Name: peptidylprolyl isomerase F
Aliases and Previous Symbols: N/A
Entrez ID: 10105
UniProt: P30405
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress- induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis. {ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:26387735}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3968
Expression level (log2 read counts): 6.68

Expression Distribution

regulation of proton-transporting ATPase activity, rotational mechanism
negative regulation of oxidative phosphorylation uncoupler activity
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
mitochondrial permeability transition pore complex
regulation of oxidative phosphorylation uncoupler activity
negative regulation of oxidative phosphorylation
mitochondrial proton-transporting ATP synthase complex
mitochondrial outer membrane permeabilization involved in programmed cell death
cellular response to arsenic-containing substance
negative regulation of release of cytochrome c from mitochondria
negative regulation of ATPase activity
positive regulation of mitochondrial membrane permeability
regulation of proton transport
necroptotic process
positive regulation of membrane permeability
cyclosporin A binding
negative regulation of ATP metabolic process
programmed necrotic cell death
regulation of necrotic cell death
positive regulation of release of cytochrome c from mitochondria
necrotic cell death
regulation of oxidative phosphorylation
response to arsenic-containing substance
protein refolding
peptidyl-prolyl cis-trans isomerase activity
protein peptidyl-prolyl isomerization
regulation of release of cytochrome c from mitochondria
response to ischemia
negative regulation of mitochondrion organization
apoptotic mitochondrial changes
peptidyl-proline modification
cellular response to hydrogen peroxide
regulation of mitochondrial membrane permeability
negative regulation of transporter activity
regulation of membrane permeability
regulation of ATPase activity
negative regulation of cation transmembrane transport
cellular response to calcium ion
negative regulation of intrinsic apoptotic signaling pathway
negative regulation of ion transmembrane transport