PPL

Entrez Summary: N/A
UniProt Summary: Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

desmosome
intermediate filament cytoskeleton organization
intermediate filament-based process
cornified envelope
structural constituent of cytoskeleton
cornification
intermediate filament
structural molecule activity
response to mechanical stimulus
keratinization
keratinocyte differentiation
cadherin binding
epidermal cell differentiation
cytoskeleton
skin development
epidermis development
wound healing
response to wounding
epithelial cell differentiation
programmed cell death
cell death
cytoskeleton organization
epithelium development
response to abiotic stimulus
mitochondrion
tissue development
membrane