PPM1E [The Human Chemical-Genetic Interaction Map Project]

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======= PPM1E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPM1E
  * **<color #00a2e8>Official Name</color>**: protein phosphatase, Mg2+/Mn2+ dependent 1E
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22843|22843]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WY54|Q8WY54]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPM1E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPM1E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619308|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11864573}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PP2C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidyl-threonine dephosphorylation|
|magnesium-dependent protein serine/threonine phosphatase activity|
|positive regulation of stress fiber assembly|
|positive regulation of actin filament bundle assembly|
|protein serine/threonine phosphatase activity|
|regulation of stress fiber assembly|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|positive regulation of supramolecular fiber organization|
|protein dephosphorylation|
|positive regulation of cytoskeleton organization|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|regulation of actin filament organization|
|negative regulation of transferase activity|
|dephosphorylation|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of actin filament-based process|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|protein-containing complex|
|positive regulation of organelle organization|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|nucleolus|
|regulation of kinase activity|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|response to drug|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of organelle organization|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.88|
|[[:results:exp539|42°C R08 exp539]]|-1.85|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.71|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.7|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9100
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPM1E Expression in NALM6 Cells: 4.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>