PPM1E

Gene Information

Official Symbol: PPM1E
Official Name: protein phosphatase, Mg2+/Mn2+ dependent 1E
Aliases and Previous Symbols: N/A
Entrez ID: 22843
UniProt: Q8WY54
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11864573}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dynasore 10μM R04 exp180	-1.88
42°C R08 exp539	-1.85
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.71
Cabazitaxel 0.001μM R05 exp223	1.7
Ethambutol 25μM R08 exp481	1.73

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9100
Expression level (log2 read counts): 4.25

Expression Distribution

peptidyl-threonine dephosphorylation
magnesium-dependent protein serine/threonine phosphatase activity
positive regulation of stress fiber assembly
positive regulation of actin filament bundle assembly
protein serine/threonine phosphatase activity
regulation of stress fiber assembly
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
positive regulation of supramolecular fiber organization
protein dephosphorylation
positive regulation of cytoskeleton organization
negative regulation of protein kinase activity
negative regulation of kinase activity
regulation of actin filament organization
negative regulation of transferase activity
dephosphorylation
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
regulation of actin filament-based process
cellular response to drug
negative regulation of protein phosphorylation
negative regulation of phosphorylation
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
protein-containing complex
positive regulation of organelle organization
negative regulation of catalytic activity
regulation of protein kinase activity
nucleolus
regulation of kinase activity
regulation of cellular component biogenesis
regulation of transferase activity
response to drug
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
positive regulation of cellular component organization